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Dwarfism in Dexter cattle is not caused by the mutations in FGFR3 responsible for achondroplasia in humans

✍ Scribed by A P Usha; D H Lester; J L Williams


Book ID
108632871
Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
224 KB
Volume
28
Category
Article
ISSN
0268-9146

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Fibroblast growth factor receptor 3 (FGFR3) is one of the four distinct membrane‐spanning tyrosine kinase receptors for fibroblast growth factors. The FGFR3 is a negative regulator of endochondral ossification and mutations in the __FGFR3__ gene have been found in patients of human hereditary diseas

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## Communicated by Lap-Chee Tsui Homozygous achondroplasia is a neonatal lethal condition which can only be diagnosed in the first trimester of pregnancy by molecular analysis. The vast majority of patients with achondroplasia have a GÃA substitution at position 1138 of the fibroblast growth facto