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Duplication of the Ph-chromosome as a possible mechanism of resistance to imatinib mesylate in patients with chronic myelogenous leukemia

✍ Scribed by A. Ossard-Receveur; A. Bernheim; B. Clausse; G. Danglot; D. Fauvet; B. Leon; F. Lozach; D. Bories; C. Brouzes; J.H. Bourhis; A.G. Turhan


Book ID
113512738
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
60 KB
Volume
163
Category
Article
ISSN
0165-4608

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✍ Hagop Kantarjian; Moshe Talpaz; Susan O'Brien; Francis Giles; Mary Beth Rios; Ke πŸ“‚ Article πŸ“… 2003 πŸ› John Wiley and Sons 🌐 English βš– 76 KB πŸ‘ 1 views

## Abstract ## BACKGROUND Obtaining a major (Philadelphia chromosome [Ph] of < 35%) or a complete cytogenetic response (Ph of 0%) has been associated with excellent long‐term survival. Cytogenetic response may continue to improve with therapy. Because early allogeneic stem cell transplantation (SC