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Duplication of exon 7–12 in the low-density lipoprotein receptor gene in three Danish patients with familial hypercholesterolemia

✍ Scribed by Feddersen, Søren; Overgaard, Martin; Nybo, Mads


Book ID
122547447
Publisher
Elsevier
Year
2013
Tongue
English
Weight
221 KB
Volume
7
Category
Article
ISSN
1933-2874

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✍ Kimiko Yamakawa; Kohki Takada; Hisako Yanagi; Shigeru Tsuchiya; Koichi Kawai; So 📂 Article 📅 1989 🏛 Springer 🌐 English ⚖ 587 KB

The low-density lipoprotein (LDL) receptor genes from 18 unrelated Japanese heterozygotes and 1 homozygote with classical familial hypercholesterolemia were analyzed by Southern blot hybridization using fragments of the human LDL receptor cDNA as probes. Four different deletion mutations were detect