Duplication of chromosome segment 12q15-24 is associated with atypical lipomatous tumors. A report of the CHAMP collaborative study group
✍ Scribed by Nils Mandahl; Måns Åkerman; Pierre Åman; Paola Dal Cin; Ivo De Wever; Christopher D. M. Fletcher; Fredrik Mertens; Felix Mitelman; Juan Rosai; Anders Rydholm; Raf Sciot; Giovanni Tallini; Herman Van den Berghe; Wim Van de Ven; Roberta Vanni; Helena Willén
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- French
- Weight
- 371 KB
- Volume
- 67
- Category
- Article
- ISSN
- 0020-7136
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✦ Synopsis
Ordinary lipomas are cytogenetically characterized by a variety of balanced rearrangements involving chromosome segment I2q 13-15, and atypical lipomatous tumors (ALT) by supernumerary ring chromosomes or giant markers known to contain amplified I2q sequences. In a series of 228 cytogenetically analyzed and histopathologically reexamined ordinary lipomas and ALT, 10 tumors showed unbalanced chromosome-I2 aberrations. All 4 tumors with loss of segments from I2q were classified as ordinary lipomas, whereas 5 of the 6 tumors showing gain of I2q material were diagnosed as ALT.
One or three extra copies of I2q15-q24 were present in all 5 ALT. We conclude that duplication of 12q sequences may be a sufficient level of amplification for development of the microscopic appearance that characterizes ALT.