✦ LIBER ✦

Duplication, divergence and formation of novel protein topologies

✍ Scribed by Christine Vogel; Veronica Morea

Publisher: John Wiley and Sons
Year: 2006
Tongue: English
Weight: 217 KB
Volume: 28
Category: Article
ISSN: 0265-9247
DOI: 10.1002/bies.20474

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✦ Synopsis

Abstract

The rearrangement or permutation of protein substructures is an important mode of divergence. Recent work1 explored one possible underlying mechanism called permutation‐by‐duplication, which produces special forms of motif rearrangements called circular permutations. Permutation‐by‐duplication, involving gene duplication, fusion and truncation, can produce fully functional intermediate proteins1 and thus represents a feasible mechanism of protein evolution. In spite of this, circular permutations are relatively rare and we discuss possible reasons for their existence. BioEssays 28: 973–978, 2006. © 2006 Wiley Periodicals, Inc.

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