✦ LIBER ✦

Ductal carcinomain situ in breast carcinogenesis

✍ Scribed by van Diest, Paul J.

Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 111 KB
Volume: 187
Category: Article
ISSN: 0022-3417
DOI: 10.1002/(sici)1096-9896(199903)187:4<383::aid-path299>3.0.co;2-h

No coin nor oath required. For personal study only.

✦ Synopsis

Evidence is mounting that ductal carcinoma in situ (DCIS) is a direct precursor of invasive breast cancer. Recent molecular biological and cytogenetic studies have revealed chromosomal gains and losses involved in breast carcinogenesis. This editorial discusses how the gains and losses on the different chromosomes fit into previously defined morphological routes of progression from normal cells through DCIS to invasive carcinoma, and the possible uses of these gains and losses in the classification of DCIS and the risk assessment of DCIS patients.

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