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Dual-specificity phosphatase 10 is fused to MDS1/EVI1-like gene 1 in a case of acute myelogenous leukemia with der(1)t(1:1)(p36.3:q21)

โœ Scribed by Mitsuho Noguchi; Haruko Tashiro; Ryosuke Shirasaki; Moritaka Gotoh; Kazuo Kawasugi; Naoki Shirafuji


Book ID
111835672
Publisher
Carden Jennings Publishing
Year
2007
Tongue
English
Weight
136 KB
Volume
85
Category
Article
ISSN
0925-5710

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## Abstract The __AML1__ gene (also known as __RUNX1__) at 21q22 codes for core binding factor (CBF) ฮฑ, which forms a heterodimer with CBF ฮฒ that acts as a transcriptional activating factor. CBF is a critical regulator in the generation and differentiation of definitive hematopoietic stem cells and