✦ LIBER ✦

Dual role of parathyroid hormone in endothelial progenitor cells and marrow stromal mesenchymal stem cells

✍ Scribed by Giovanni Di Bernardo; Umberto Galderisi; Carmela Fiorito; Tiziana Squillaro; Letizia Cito; Marilena Cipollaro; Antonio Giordano; Claudio Napoli

Publisher: John Wiley and Sons
Year: 2010
Tongue: English
Weight: 292 KB
Volume: 222
Category: Article
ISSN: 0021-9541
DOI: 10.1002/jcp.21976

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Hematopoietic stem cells derive regulatory information also from parathyroid hormone (PTH). To explore the possibility that PTH may have a role in regulation of other stem cells residing in bone marrow, such as mesenchymal stem cells (MSCs) and endothelial progenitor cells (EPCs) we assessed the effect of this hormone on the in vitro behavior of MSCs and EPCs. We evidenced that MSCs were much more responsive to PTH than EPCs. PTH increased the proliferation rate of MSCs with a diminution of senescence and apoptosis. Taken together, our results may suggest a protective effect of PTH on MSCs that reduces stress phenomena and preserve genome integrity. At the opposite, PTH did not modify the fate of EPCs in culture. J. Cell. Physiol. 222: 474–480, 2010. © 2009 Wiley‐Liss, Inc.

📜 SIMILAR VOLUMES

Role of RB and RB2/P130 genes in marrow

Role of RB and RB2/P130 genes in marrow stromal stem cells plasticity

✍ Francesco P. Jori; Marco A. Napolitano; Mariarosa A.B. Melone; Marilena Cipollar 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 322 KB

Marrow stromal cells (MSCs) are stem-like cells having a striking somatic plasticity. In fact, besides differentiating into mesenchymal lineages (bone, cartilage, and fat), they are capable of differentiating into neurons and astrocytes in vitro and in vivo. The RB and RB2/P130 genes, belonging to t

The role of BMP-7 in chondrogenic and os

The role of BMP-7 in chondrogenic and osteogenic differentiation of human bone marrow multipotent mesenchymal stromal cells in vitro

✍ Bojiang Shen; Aiqun Wei; Shane Whittaker; Lisa A. Williams; Helen Tao; David D.F 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 423 KB 👁 1 views

This study addresses the role of bone morphogenetic protein-7 (BMP-7) in chondrogenic and osteogenic differentiation of human bone marrow multipotent mesenchymal stromal cells (BM MSCs) in vitro. BM MSCs were expanded and differentiated in the presence or absence of BMP-7 in monolayer and three-dime

EXPRESSION OF THE CELL ADHESION MOLECULE

EXPRESSION OF THE CELL ADHESION MOLECULE E-CADHERIN BY THE HUMAN BONE MARROW STROMAL CELLS AND ITS PROBABLE ROLE IN CD34+STEM CELL ADHESION

✍ K.R. Turel; S.G.A. Rao 📂 Article 📅 1998 🏛 Elsevier Science 🌐 English ⚖ 277 KB

Bone marrow stroma is the physical basis of the haematopoietic microenvironment and regulates several key features of stem cell proliferation and differentiation. It plays a crucial role in maintaining haematopoietic homeostasis. Earlier studies have shown that this is achieved through interactions

Effect of dual growth factor delivery on

Effect of dual growth factor delivery on chondrogenic differentiation of rabbit marrow mesenchymal stem cells encapsulated in injectable hydrogel composites

✍ Hansoo Park; Johnna S. Temenoff; Yasuhiko Tabata; Arnold I. Caplan; Robert M. Ra 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 332 KB

## Abstract An injectable hydrogel composite consisting of oligo(poly(ethylene glycol)fumarate) (OPF) and gelatin microparticles has been developed as a novel carrier system for cells and growth factors. Rabbit marrow mesenchymal stem cells (MSCs) and gelatin microparticles (MPs) loaded with insuli