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Dual regulation of the ΔNp63 transcriptional activity by ΔNp63 in human nasopharyngeal carcinoma cell

✍ Scribed by Wing-Keung Chu; Kuei-Ching Lee; Shu-Er Chow; Jan-Kan Chen

Book ID
116292480
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
230 KB
Volume
342
Category
Article
ISSN
0006-291X

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Overexpression of ΔNp63 in a human nasop
Overexpression of ΔNp63 in a human nasopharyngeal carcinoma cell line downregulates CKIs and enhances cell proliferation
✍ Chi-Tai Chiang; Wing-Keung Chu; Shu-Er Chow; Jan-Kan Chen 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 219 KB

## Abstract p63 belongs to a member of the tumor suppressor protein p53 family. Due to alternative promoter usage, two types of p63 proteins are produced. The ΔNp63 isoform lacks the N‐terminal transactivation domain and is thought to antagonize TAp63 and p53 in target gene regulation. ΔNp63 has be