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Dual regulation of metalloproteinase expression in chondrocytes by Wnt-1–inducible signaling pathway protein 3/CCN6

✍ Scribed by Natasha Baker; Paul Sharpe; Kirsty Culley; Miguel Otero; Damon Bevan; Peter Newham; Wendy Barker; Kristen M. Clements; Caroline J. Langham; Mary B. Goldring; Jelena Gavrilović


Book ID
112002705
Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
404 KB
Volume
64
Category
Article
ISSN
0004-3591

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## Abstract Transforming growth factor (TGF‐β1) is a potent inducer of chondrogenesis and stimulant of cartilage extracellular matrix (ECM) synthesis. Tissue inhibitor of metalloproteinases‐3 (TIMP‐3) is located in ECM and is the major inhibitor of matrix metalloproteinases (MMPs) and aggrecanase,