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Dual phase and rate coding in hippocampal place cells: Theoretical significance and relationship to entorhinal grid cells

✍ Scribed by John O'Keefe; Neil Burgess

Publisher: John Wiley and Sons
Year: 2005
Tongue: English
Weight: 978 KB
Volume: 15
Category: Article
ISSN: 1050-9631
DOI: 10.1002/hipo.20115

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✦ Synopsis

Abstract

We review the ideas and data behind the hypothesis that hippocampal pyramidal cells encode information by their phase of firing relative to the theta rhythm of the EEG. Particular focus is given to the further hypothesis that variations in firing rate can encode information independently from that encoded by firing phase. We discuss possible explanation of the phase‐precession effect in terms of interference between two independent oscillatory influences on the pyramidal cell membrane potential, and the extent to which firing phase reflects internal dynamics or external (environmental) variables. Finally, we propose a model of the firing of the recently discovered “grid cells” in entorhinal cortex as part of a path‐integration system, in combination with place cells and head‐direction cells. © 2005 Wiley‐Liss, Inc.

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## Abstract As a rat navigates through a familiar environment, its position in space is encoded by firing rates of place cells and grid cells. Oscillatory interference models propose that this positional firing rate code is derived from a phase code, which stores the rat's position as a pattern of