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Dual Modulation of ERK1/2 and p38 MAP Kinase Activities Induced by Minocycline Reverses the Neurotoxic Effects of the Prion Protein Fragment 90–231

✍ Scribed by Alessandro Corsaro; Stefano Thellung; Katia Chiovitti; Valentina Villa; Alessandro Simi; Federica Raggi; Domenico Paludi; Claudio Russo; Antonio Aceto; Tullio Florio

Book ID
107677976
Publisher
Springer-Verlag
Year
2009
Tongue
English
Weight
579 KB
Volume
15
Category
Article
ISSN
1029-8428

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## Abstract Astrogliosis and microglial activation are a common feature during prion diseases, causing the release of chemoattractant and proinflammatory factors as well as reactive free radicals, involved in neuronal degeneration. The recombinant protease‐resistant domain of the prion protein (PrP