Dual MAP kinase pathways mediate opposing forms of long-term plasticity at CA3–CA1 synapses

Plasticity of synaptic glun receptors is

Plasticity of synaptic glun receptors is required for the Src-dependent induction of long-term potentiation at CA3-CA1 synapses

✍ Hong-Bin Li; Michael F. Jackson; Kai Yang; Catherine Trepanier; Michael W. Salte 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 334 KB

## Abstract The induction of long‐term potentiation (LTP) of CA3‐CA1 synapses requires activation of postsynaptic __N__‐methyl‐D‐aspartate receptors (GluNRs). At resting potential, the contribution of GluNRs is limited by their voltage‐dependent block by extracellular Mg^2+^. High‐frequency afferen