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Dual-Growth-Factor-Releasing PCL Scaffolds for Chondrogenesis of Adipose-Tissue-Derived Mesenchymal Stem Cells

✍ Scribed by Sung Mook Lim; Sung Hwan Jang; Se Heang Oh; Soon Hong Yuk; Gun Il Im; Jin Ho Lee

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
857 KB
Volume
12
Category
Article
ISSN
1438-1656

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✦ Synopsis

Abstract

Polycaprolactone/Pluronic F127 porous scaffolds are prepared using a modified melt‐molding particulate‐leaching method. The scaffolds are highly porous (about 90% porosity) and have open‐cellular pore structures. Growth factors (TGF‐β~2~, BMP‐7 or dual TGF‐β~2~/BMP‐7) can be easily immobilized on the pore surfaces of the PCL/F127 scaffolds via binding with heparin. The growth‐factor‐immobilized scaffolds can induce the chondrogenesis of ATMSCs seeded onto them. Using TGF‐β~2~ and BMP‐7 growth factors together leads to a better chondrogenic differentiation behavior than using single‐growth‐factor immobilized scaffolds.

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