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Dual Effects of Na/K Pump Inhibition on Cytoplasmic Ca2+ Oscillations in Pancreatic β-Cells

✍ Scribed by E. Grapengiesser; A. Berts; S. Saha; P.E. Lund; E. Gylfe; B. Hellman

Book ID
115564253
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
500 KB
Volume
300
Category
Article
ISSN
0003-9861

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The effect of carbachol on the cytoplasmic Ca2+ concentration [( Ca2+]i) was studied in insulin-releasing mouse pancreatic beta cells hyperpolarized by the K(+)-channel-activating agent diazoxide. By mobilizing intracellular Ca2+, carbachol induced an initial [Ca2+]i transient, which was more than t