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Dual effects of histamine and substance P on intracellular calcium levels in human U373 MG astrocytoma cells: role of protein kinase C

โœ Scribed by K W. Young; R D. Pinnock; W J. Gibson; J M. Young

Book ID
110003397
Publisher
Nature Publishing Group
Year
1998
Tongue
English
Weight
461 KB
Volume
123
Category
Article
ISSN
0007-1188

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โœ A. Bordey; P. Feltz; J. Trouslard ๐Ÿ“‚ Article ๐Ÿ“… 1994 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 629 KB

Variations in intracellular free calcium concentration (A1Cazfli) were measured in intact and isolated human astrocytoma cells (U373 MG) loaded with fura-2 acetoxymethylester. Microperfusion of 50 nM substance P (SP), applied for 1 s, increased [Ca" ' Ii by 351 nM from a stable basal level of [Ca2+l