Dual Effect of Synthetic Aminoglycosides: Antibacterial Activity against Bacillus anthracis and Inhibition of Anthrax Lethal Factor

✍ Scribed by Micha Fridman; Valery Belakhov; Lac V. Lee; Fu-Sen Liang; Chi-Huey Wong; Timor Baasov

• Publisher: John Wiley and Sons
• Year: 2005
• Tongue: English
• Weight: 143 KB
• Volume: 44
• Category: Article
• ISSN: 0044-8249
• DOI: 10.1002/anie.200462003

✦ Synopsis

Anthrax is an infectious disease caused by toxigenic strains of the Gram-positive Bacillus anthracis. [1] If inhaled, B. anthracis spores rapidly reach the regional lymphonodes of the lungs, where they germinate and release anthrax toxins. [2] These toxins inhibit the adaptive immune response, thereby enabling the bacteria to reach the blood system, where they cause bacteremia and toxemia, which rapidly kill the host. Nontoxigenic strains of B. anthracis are poorly pathogenic, thus indicating that the anthrax toxins play a major role from the [*] Dr.