Dual CD system in capillary electrophoresis for direct separation of the four stereoisomers of agonist and antagonist melatoninergic ligands

Chiral separation of the four stereoisom

Chiral separation of the four stereoisomers of a novel antianginal agent using a dual cyclodextrin system in capillary electrophoresis

✍ Martine Beaufour; Philippe Morin; Jean-Paul Ribet 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 660 KB

Reported here is an analytical method enabling the stereochemical resolution of a new antianginal compound possessing two stereogenic centers, leading to four stereoisomers. Only one of these isomers is currently under development as a novel antianginal agent and consequently, the other three isomer