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Dual blockade of EGFR and ERK1/2 phosphorylation potentiates growth inhibition of breast cancer cells

✍ Scribed by Lev, D C; Kim, L S; Melnikova, V; Ruiz, M; Ananthaswamy, H N; Price, J E


Book ID
109998206
Publisher
Nature Publishing Group
Year
2004
Tongue
English
Weight
194 KB
Volume
91
Category
Article
ISSN
0007-0920

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## Abstract ## BACKGROUND. Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR‐TKIs) have demonstrated clinical benefit in patients with nonsmall cell lung cancer (NSCLC), particularly those with tumors that have EGFR‐TK domain mutations. Moreover, the EGFR and cyclooxygenase (COX)‐2