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Dual antitumor mechanisms of Notch signaling inhibitor in a T-cell acute lymphoblastic leukemia xenograft model

✍ Scribed by Shigeo Masuda; Keiki Kumano; Takahiro Suzuki; Taisuke Tomita; Takeshi Iwatsubo; Hideaki Natsugari; Arinobu Tojo; Makoto Shibutani; Kunitoshi Mitsumori; Yutaka Hanazono; Seishi Ogawa; Mineo Kurokawa; Shigeru Chiba


Book ID
108586512
Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
597 KB
Volume
100
Category
Article
ISSN
1347-9032

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## Abstract Over the past 20 years, survival rates of T‐cell acute lymphoblastic leukemia (T‐ALL) patients have improved, mainly because of advances in polychemotherapy protocols. Despite these improvements, we still need novel and less toxic treatment strategies targeting aberrantly activated sign