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Dual antiplatelet therapy in surgery for critical limb ischaemia

✍ Scribed by A. Burdess; A. Nimmo; O. J. Garden; J. A. Murie; A. R. Dawson; K. A. A. Fox; D. E. Newby

Publisher: John Wiley and Sons
Year: 2009
Tongue: English
Weight: 71 KB
Volume: 96
Category: Article
ISSN: 0007-1323
DOI: 10.1002/bjs.6503

No coin nor oath required. For personal study only.

✦ Synopsis

VSGBI abstracts 5 (0•82 [0•52-1•46] versus 1•62 [0•86-2•34], p < 0•001), yet soluble P-selectin was significantly increased (43•26 [13•88-86•7] versus 24•67 [13•41-43•32], p = 0•039). Stimulated P-selectin was similar in both groups. Markers of coagulation were significantly increased in patients on HD: TAT 4•59 (2•67-6•04) versus 2•84 (1•81-3•82), p < 0•001 and D-dimer 876•5 (434•2-1338•5) versus 265•5 (175•0-401•51), p < 0•001.

Conclusion:

Patients on HD have a pro-thrombotic state with chronically activated platelets and elevated markers of coagulation. Drug therapy to counteract this pro-thrombotic state should be considered with the aim of preventing both cardiac events and vascular access thrombosis.

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