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Dual and selective antagonism of neurokinin NK1and NK2receptor-mediated responses in human colon mucosa

✍ Scribed by Iain R. Tough; Christine A. Lewis; John Fozard; Helen M. Cox

Book ID
105876175
Publisher
Springer-Verlag
Year
2003
Tongue
English
Weight
261 KB
Volume
367
Category
Article
ISSN
0028-1298

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Neurokinin-1 receptor (NK-1R) expression
Neurokinin-1 receptor (NK-1R) expression is induced in human colonic epithelial cells by proinflammatory cytokines and mediates proliferation in response to substance P
✍ Triona Goode; Terry O'Connor; Ann Hopkins; Derek Moriarty; Gearld C. O'Sullivan; πŸ“‚ Article πŸ“… 2003 πŸ› John Wiley and Sons 🌐 English βš– 628 KB

## Abstract We have previously shown that the receptor for substance P (SP), neurokinin‐1 receptor (NK‐1R), is a marker of human mucosal but not peripheral mononuclear cells. In the present study, we investigate NK‐1R expression in the human colonic mucosa in vivo, particularly in the epithelial ce