𝔖 Bobbio Scriptorium
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DST in depression is unaffected by altering the clock time of its administration

✍ Scribed by Gary M. Pepper; Kenneth L. Davis; Bonnie M. Davis; Dorothy T. Krieger


Book ID
119094429
Publisher
Elsevier Science
Year
1983
Tongue
English
Weight
359 KB
Volume
8
Category
Article
ISSN
0165-1781

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Previous studies have demonstrated that there are circadian rhythms in susceptibility to a range of commonly used cytotoxic drugs. In this study we have compared the pharmacokinetics and myelotoxicity of carboplatin administered at 18.00 and 06.00 in random order in patients with advanced ovarian ca