The myelotoxicity of carboplatin is infl
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D. J. Kerr; C. Lewis; B. O'Neil; N. Lawson; R. G. Blackie; D. R. Newell; F. Boxa
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Article
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1990
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John Wiley and Sons
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English
⚖ 329 KB
Previous studies have demonstrated that there are circadian rhythms in susceptibility to a range of commonly used cytotoxic drugs. In this study we have compared the pharmacokinetics and myelotoxicity of carboplatin administered at 18.00 and 06.00 in random order in patients with advanced ovarian ca