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Dryofragin, a phloroglucinol derivative, induces apoptosis in human breast cancer MCF-7 cells through ROS-mediated mitochondrial pathway

✍ Scribed by Zhang, Ying; Luo, Meng; Zu, Yuangang; Fu, Yujie; Gu, Chengbo; Wang, Wei; Yao, Liping; Efferth, Thomas


Book ID
118427672
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
940 KB
Volume
199
Category
Article
ISSN
0009-2797

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## Abstract Rotenone is an inhibitor of the mitochondrial electron transport chain complex I, resulting in the generation of reactive oxygen species (ROS). Rotenone has been shown to display anticancer activity through the induction of apoptosis in various cancer cells. However, the underlying mech