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Drugs of Abuse and Stress Trigger a Common Synaptic Adaptation in Dopamine Neurons

โœ Scribed by Daniel Saal; Yan Dong; Antonello Bonci; Robert C Malenka

Book ID
117608505
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
182 KB
Volume
37
Category
Article
ISSN
0896-6273

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Many classes of drugs abused by man share with natural rewards the ability to increase dopamine (DA) release in the nucleus accumbens (NAc) bf the rat. However, this is unlikely to account for the rewarding effects of drugs of abuse, as NAc DA release is equally increased by aversive stimuli, and ev