We have tested several solvents for the decontamination of control hair contaminated by cocaine. Methylene chloride was the most efficient solvent, eliminating more than 60% of contaminating cocaine. Two washes were used, additional washes were not effective in removing more cocaine. Sixteen hair a
Drugs in hair: A new extraction procedure
โ Scribed by C. Offidani; A. Carnevale; M. Chiarotti
- Publisher
- Elsevier Science
- Year
- 1989
- Tongue
- English
- Weight
- 236 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0379-0738
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โฆ Synopsis
An enzymatic hydrolysis of hair for drug detection is described. The results obtained with the suggested method are compared with those observed by chemical hydrolysis. Enzymatic digestion provides a high recovery (80%) for cocalne metabolite. while alkaline hydrolysis causes its chemical destruction. The two hydrolytic procedures yielded comparable results for morphine. The outlined procedure is recommended when unstable compounds are to be detected in hair.
๐ SIMILAR VOLUMES
The use of an ion trap mass spectrometer for the detection, via tandem mass spectrometry, of morphine and cocaine in the hair of drug addicts proved to be successful. In particular, detection limits of 1-20 ppb for morphine and 5-30 ppb for cocaine were achieved, with good reproducibility and absenc