𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Drug—membrane interactions: Silymarin, silibyn and microsomal membranes

✍ Scribed by T. Parasassi; A. Martellucci; F. Conti; B. Messina

Book ID
101819805
Publisher
John Wiley and Sons
Year
1984
Tongue
English
Weight
381 KB
Volume
2
Category
Article
ISSN
0263-6484

No coin nor oath required. For personal study only.

✦ Synopsis

Silymarin and silibyn are extracted from the seeds of Silybum marianum and used as a liver protectant because of their free radical scavenging. When incorporated into rabbit liver microsomes they cause a small decrease in the flourescence anisotropy of 1,6-diphenyl-1,3,5-hexatriene (DPH) but not of 1-anilinononaphthalene-8-sulphonic acid (ANS), incorporated into the membranes. They do, however, reduce the fluorescence intensity of incorporated ANS without changing the wavelength of maximum intensity. These observations suggest that the drugs are incorporated into the hydrophobic-hydrophilic interface of the microsomal bilayer and perturb the structure by influencing the packing of the acyl chains.

📜 SIMILAR VOLUMES

Drug-Membrane Interactions: Analysis, Dr
Drug-Membrane Interactions: Analysis, Drug Distribution, Modeling
✍ Seydel J., Wiese M. 📂 Library 📅 2002 🌐 English ⚖ 3 MB

Barrier, reservoir, target site - those are but some of the possible functions of biological lipid membranes in the complex interplay of drugs with the organism. A detailed knowledge of lipid membranes and of the various modes of drug-membrane interaction is therefore the prerequisite for a better u

Drug-membrane interactions analysis, dru
Drug-membrane interactions analysis, drug distribution, modelling
✍ Joachim K. Seydel, Michael Wiese, Raimund Mannhold, Hugo Kubinyi, Gerd Folkers 📂 Library 📅 2002 🏛 Wiley-VCH 🌐 English ⚖ 4 MB

Barrier, reservoir, target site - those are but some of the possible functions of biological lipid membranes in the complex interplay of drugs with the organism. A detailed knowledge of lipid membranes and of the various modes of drug-membrane interaction is therefore the prerequisite for a better u