Drug treatment of supraventricular arrhythmias

• Publisher: Springer US
• Year: 1991
• Tongue: English
• Weight: 328 KB
• Volume: 5
• Category: Article
• ISSN: 0920-3206
• DOI: 10.1007/bf00055744

✦ Synopsis

Drug Treatment of Supraventricular Arrhythmias P125 FLE£,AINIDE (F) ~N) I:~P~ENONE (P) 1N ]HE ]W:A'Ii,ENT OF [email protected]~. All~Lq_ FIBRILLATION (P~). M.Balducelli,~.Fab~,A.i~aresta, Oepar~ of Caroiology, Ospedale per gli Infermi, F)~B~.A, IT&Y.

~ehaserar~4bpatients with recent omet PAF to trea~mmt with P or F. N~dy had evidence of significant heart di__~ee~ (ECO,ECG), electrolyte imbalance or thyroid dysfunction. Median age was 5~14 yrs (range 22-75). F was admini~ as repeated boluses of 2, 0.5 and 0.5 R]/k9; P as a bolus of 2 n~kg and successive infusion of 0.007 ng/kg/min for 6 hours. Crossover was performedaft~rIZ~if ~e first drug was not effective. 26 patients received P as first choice drug wi~h conversion to sinus rhyc~ in 20 (T/t), ZOF was effective in 16 (~). P w~s employed as second choice drug in 2 c~ without success and F in 3 with efficacy. THe remaining failures refused ho~italisation or returned ~or~ly to sinus rhy~. F ca_~ed__ symptomtic hypo~ion in 2 pts with ~cia~ed br-adycardia in one. No adverseeffectwesob~ervedwi~P. Mean time of o0nveraion to sinus rhy~ has been I~ minutes for F vs 150~_139 for P (pKO.OU~). Total effectiveness has been 71t for P and ~ for F (NS).

In conclusion both i.v. P and F at these doses have shown to be effective in the 0mversi0n of recent onset A c to sinus rhy~.