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Drug Trapping in hERG Channels does not Require Closure of the Activation Gate

✍ Scribed by Saxena, Priyanka; Erker, Thomas; Bauer, Florian; Stary-Weinzinger, Anna; Linder, Tobias; Hering, Steffen; Timin, Eugen


Book ID
122694516
Publisher
Biophysical Society
Year
2013
Tongue
English
Weight
41 KB
Volume
104
Category
Article
ISSN
0006-3495

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Evoked potentials recorded from slices of pigeon hippocampus were reversibly attenuated by 2 mM kynurenic acid. High frequency stimulation (3 x 200 Hz for 1 sec, with 1 sec intervals) evoked a persistent increase in the evoked potential, lasting in a nondecremental form for at least 2 hr. This incre