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Drug transport and metabolism characteristics of the human airway epithelial cell line Calu-3

✍ Scribed by Bogdan I. Florea; Maria L. Cassara; Hans E. Junginger; Gerrit Borchard

Book ID
114161997
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
424 KB
Volume
87
Category
Article
ISSN
0168-3659

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Transport and local metabolism of budeso
Transport and local metabolism of budesonide and fluticasone propionate in a human bronchial epithelial cell line (Calu-3)
✍ Gerrit Borchard; MarΓ­a Luz CassarΓ‘; Peter E.H. RoemelΓ©; Bogdan I. Florea; Hans E πŸ“‚ Article πŸ“… 2002 πŸ› John Wiley and Sons 🌐 English βš– 103 KB

Calu-3 cells grown on microporous filters at an air interface for 16-18 days were incubated with the glucocorticosteroid (GCS) budesonide (BUD). Apparent permeability (P(app)) of BUD across Calu-3 cell monolayers was determined. Amount of BUD transported across Calu-3 cells was clearly concentration