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Drug therapy of frontotemporal dementia

✍ Scribed by Hervé Allain; Danièle Bentué-Ferrer; Olivier Tribut; Marc Mérienne; Serge Belliard

Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
68 KB
Volume
18
Category
Article
ISSN
0885-6222

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✦ Synopsis

Abstract

Frontal lobe dementia, or more generally frontotemporal dementia (FTD), includes several clinical entities and, although highly prevalent, lacks any codified therapeutic strategy. The present review is an attempt to depict the main neurochemical correlates of FTD and, as a consequence, to propose the most sound targets for symptomatic drugs. Large scale double‐blind controlled clinical trials should be carried out to test any hypothesis: serotonergic agents, glutamate neurotransmission enhancers, monoamine oxidase inhibitors. The recent discovery of tau gene mutations in FTD with Parkinsonism linked to chromosome 17 has reinforced the direct role attributed to abnormal tau proteins (hyperphosphorylation) and thus raised the possibility to target specifically these processes by drugs (aetiopathogenic compounds). Copyright © 2003 John Wiley & Sons, Ltd.

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