✦ LIBER ✦

Drug targeting to the liver with bile acids: THE “trojan horse” resurrected?

✍ Scribed by Dirk K. F. Meijer

Publisher: John Wiley and Sons
Year: 1993
Tongue: English
Weight: 457 KB
Volume: 17
Category: Article
ISSN: 0270-9139
DOI: 10.1002/hep.1840170528

No coin nor oath required. For personal study only.

✦ Synopsis

Bile acids are selectively taken up from portal blood into the liver by specific transport systems in the hepatocyte plasma membrane. Therefore, studies were performed to evaluate the potential of bile acids as shuttles to deliver drugs specifically to the liver. The alkylating cytostatic drug chlorambucil and the fluorescent prolyl-4-hydroxylase inhibitor 4-nitroben-

📜 SIMILAR VOLUMES

Drug targeting to the liver with lactosy

Drug targeting to the liver with lactosylated albumins: Does the glycoprotein target the drug or is the drug targeting the glycoprotein?

✍ Peter van der Sluijs; Hans P. Bootsma; Bart Postema; Frits Moolenaar; Dirk K. F. 📂 Article 📅 1986 🏛 John Wiley and Sons 🌐 English ⚖ 775 KB

The isolated perfused rat liver preparation was employed to study hepatic disposition of the model drugcarrier conjugate fluorescein-lactosylated albumin (F-L.HSA) with special reference to the influence of the organic anion fluorescein on liver cell specificity of the endocytomd neoglycoprotein. He