Drug sensitivity studies on clonal cell lines isolated from heteroploid tumour cell populations. I. Dose response of clones growing in monolayer cultures
✍ Scribed by I. Pályi; Edit Oláh; J. Sugár
- Publisher
- John Wiley and Sons
- Year
- 1977
- Tongue
- French
- Weight
- 638 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0020-7136
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✦ Synopsis
Drug sensitivity of a heteroploid tumour cell line and three clones isolated from it was studied in tissue culture. Cells of the parent line, PO, and of clone P, were fibroblast-like and pseudo-and hypodiploid. Clones P, and P, consisted mostly of epithelial and round cells, respectively, and were hypotetraploid. In dose-response experiments, P, and P, clones were more sensitive to dianhydrodulcitol than Po or P, clones. Adriamycin was more toxic to P, than to the other three cell lines. Pa and P, clones were more sensitive to vincristine than Po or P, clones. N-formyl-leurosine, a new derivative of the Vinca alkaloids, was least toxic to P, cells, and the other three cell lines were equally sensitive. It was concluded that relative sensitivity of the clones depended on the particular drug. Presence of clones of lower sensitivity in heteroploid cell populations may have some bearing on regrowth of tumours after chemotherapy.