Drug Self-Templated Synthesis of Ibuprofen/Mesoporous Silica for Sustained Release

✍ Scribed by Fengyu Qu; Guangshan Zhu; Huiming Lin; Jinyu Sun; Daliang Zhang; Shougui Li; Shilun Qiu

• Book ID: 102170128
• Publisher: John Wiley and Sons
• Year: 2006
• Tongue: English
• Weight: 160 KB
• Volume: 2006
• Category: Article
• ISSN: 1434-1948
• DOI: 10.1002/ejic.200501035

✦ Synopsis

Abstract

The synthesis of Ibuprofen/mesoporous silica has been achieved by a drug self‐templated one‐step co‐condensation process. The drug template of Ibuprofen, a co‐template of 3‐aminopropyltriethoxysilane (APTES), and tetraethoxysiliane (TEOS) were self‐assembled into Ibuprofen/mesoporous silica in a neutral aqueous reaction system. This drug/mesoporous silica was characterized by powder XRD diffraction, FTIR spectroscopy, N~2~ adsorption/desorption, TEM, and ^29^Si/MAS and ^13^C/MAS NMR spectroscopy. The Ibuprofen/mesoporous silica system gives a well‐sustained release profile. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)