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Drug retention, efflux, and resistance in tumor cells

✍ Scribed by Awtar Krishan; Catherine Morgan Fitz; Ilia Andritsch

Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
54 KB
Volume
29
Category
Article
ISSN
0196-4763

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✦ Synopsis

Multiple drug resistance (MDR) in tumor cells has been related to the expression of transport proteins which alter cellular drug transport and distribution. Three different genes (mdr, MRP, and LRP) and their products have been implicated in MDR. Several fluorescent dyes have been used to monitor the effect of these transport proteins on drug retention, as well as for screening of drugs which block drug efflux and thus enhance cellular drug retention and cytotoxicity. The present review summarizes current knowledge about MDR phenotypic markers and techniques available for study of MDR by flow cytometry. Cytometry 29:279-285, 1997.

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