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Drug-resistant mutants of chinese hamster ovary cells possess an altered cell surface carbohydrate component

✍ Scribed by Juliano, Rudy ;Ling, Victor ;Graves, James

Publisher
Wiley (John Wiley & Sons)
Year
1976
Tongue
English
Weight
291 KB
Volume
4
Category
Article
ISSN
0091-7419

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✦ Synopsis

Abstract

Surface label experiments using the galactose oxidase‐[^3^ H] ‐borohydride technique reveal that cells from drug‐resistant Chinese hamster ovary clones possess a surface carbohydrate component of apparent molecular weight 165,000 which is absent from wild‐type cells. The component may also be demonstrated by [^14^C] glucosamine incorporation but not by [^3^ H] leucine incorporation or by the lactoperoxidase surface labeling reaction.

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