Drug-resistant bullous pemphigoid and inflammatory bowel disease in a pediatric case successfully treated by plasma exchange and extracorporeal photochemotherapy
✍ Scribed by Gino Tripodi; Marco Risso; Loredana Tenerini; Paolo Gandullia; Emanuela Castellano; Lucia Rivabella
- Book ID
- 102296335
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 259 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0733-2459
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✦ Synopsis
Abstract
Bullous pemphigoid (BP) is an autoimmune skin disease that occurs mainly in elderly patients; onset of BP is rare in childhood. Inflammatory bowel diseases (IBD), by contrast, have a pediatric onset in 25% of presenting cases, requiring expert multidisciplinary management. Here we report a pediatric case of IBD (involving stomach, duodenum, ileum, and colon‐rectum) associated with a disseminated form of drug‐resistant BP successfully treated by plasma exchange (PEX), extracorporeal photochemotherapy (ECP), and corticosteroid therapy. The addition of PEX and ECP to standard treatment induced no severe side effects, prompted a rapidly achieved complete and long‐term remission, and allowed dose tapering of the immunosuppressive drugs over an 18‐month follow‐up. J. Clin. Apheresis. 22:, 2007 © 2007 Wiley‐Liss, Inc.