Drug Repositioning (Bringing New Life to Shelved Assets and Existing Drugs) || Mining Scientific and Clinical Databases to Identify Novel Uses for Existing Drugs

✍ Scribed by Barratt, Michael J.; Frail, Donald E.

• Book ID: 120221472
• Publisher: John Wiley & Sons, Inc.
• Year: 2012
• Tongue: English
• Weight: 196 KB
• Edition: 1
• Category: Article
• ISBN: 0470878274
• DOI: 10.1002/9781118274408.ch6

✦ Synopsis

Drug Repositioning : The Business Case And Current Strategies To Repurpose Shelved Candidates And Marketed Drugs / John Arrowsmith And Richard Harrison -- Opportunities And Challenges Associated With Developing Additional Indications For Clinical Development Candidates And Marketed Drugs / Donald E. Frail And Michael J. Barratt -- Clinical And Operational Considerations In Repositioning Marketed Drugs And Drug Candidates / Damian O'connell, David J. Sequeira, And Maria L.miller -- Regulatory Considerations And Strategies For Drug Repositioning / Ken Phelps -- Computational And Bioinformatic Strategies For Drug Repositioning / Richard Mazzarella And Craig Webb -- Mining Scientific And Clinical Databases To Identify Novel Uses For Existing Drugs / Christos Andronis ... [et Al.] -- Predicting The Polypharmacology Of Drugs : Identifying New Uses Through Chemoinformatics, Structural Informatics, And Molecular Modeling-based Approaches / Li Xie ... [et Al.] -- Systematic Phenotypic Screening For Novel Synergistic Combinations: A New Paradigm For Repositioning Existing Drugs / Margaret S. Lee -- Phenotypic In Vivo Screening To Identify New, Unpredicted Indications For Existing Drugs And Drug Candidates / Michael S. Saporito, Christopher A. Lipinski, And Andrew G. Reaume -- Old Drugs Yield New Discoveries : Examples From The Prodrug, Chiral Switch And Site-selective Deuteration Strategies / Adam J. Morgan ... [et Al.] -- Repurposing Drugs For Tropical Diseases : Case Studies And Open-source Screening Initiatives / Curtis R. Chong -- Drug Repositioning Efforts By Nonprofit Foundations -- Business Development Strategies In The Repositioning Industry / Aris Persidis And Elizabeth T. Stark -- A Case Study In Drug Repositioning : Sosei / Akinori Mochizuki And Makiko Aoyama. Edited By Michael J. Barratt, Donald E. Frail. Includes Bibliographical References And Index.