Drug release testing of a prostaglandin containing controlled-release vaginal device: Development of a semi-automated method

Once-a-day controlled-release dosage for

Once-a-day controlled-release dosage form of divalproex sodium II: Development of a predictive in vitro drug release method

✍ Yihong Qiu; J. Garren; E. Samara; G. Cao; C. Abraham; H.S. Cheskin; K.R. Engh 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 207 KB 👁 1 views

During formulation design of a once-daily controlled release matrix system of divalproex sodium, the in vitro dissolution test (USP II, 100 rpm, pH 6.8 buffer) was found to result in release rates that were slower than in vivo absorption. The test method also did not sufficiently discriminate formul