Drug Release of pH/Temperature-Responsive Calcium Alginate/Poly(N-isopropylacrylamide) Semi-IPN Beads

✍ Scribed by Jun Shi; Natália M. Alves; João F. Mano

• Publisher: John Wiley and Sons
• Year: 2006
• Tongue: English
• Weight: 130 KB
• Volume: 6
• Category: Article
• ISSN: 1616-5187
• DOI: 10.1002/mabi.200600013

✦ Synopsis

Abstract

Summary: A series of semi‐interpenetrating, polymer network (semi‐IPN), hydrogel beads, composed of calcium alginate (Ca‐alginate) and poly(N‐isopropylacrylamide) (PNIPAAM), were prepared for a pH/temperature‐sensitive drug delivery study. The equilibrium swelling showed the independent pH‐ and thermo‐ responsive nature of the developed materials. At pH = 2.1, the release amount of indomethacin incorporated into these beads was about 10% within 400 min, while this value approached to 95% at pH = 7.4. The release rate of the drug was higher at 37 °C than that at 25 °C and increased slightly with increasing PNIPAAM content. These results suggest that the Ca‐alginate/PNIPAAM beads have the potential to be used as an effective pH/temperature sustainable delivery system of bioactive agents.

A summary of the temperature‐ and pH‐dependence on the release of the drug over a period of 450 min. The effect of the temperature on the swelling of the beads is shown in the inset.

magnified imageA summary of the temperature‐ and pH‐dependence on the release of the drug over a period of 450 min. The effect of the temperature on the swelling of the beads is shown in the inset.