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Drug release from hydroxypropyl cellulose-polyvinyl acetate films

โœ Scribed by Saul Borodkin; Florence E. Tucker


Publisher
John Wiley and Sons
Year
1974
Tongue
English
Weight
612 KB
Volume
63
Category
Article
ISSN
0022-3549

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Release of drug from a single-layer film containing dispersed drug follows a diffusion-controlled matrix model, where the quantity released per unit area is proportional to the square root of time. The kinetics may be made linear with time (zero order) by laminating a second film without drug to the

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The influence of commonly used excipients, spray-dried lactose (SDL), microcrystalline cellulose (MCC), and partially pregelatinized maize starch (Starch 1500 1 ) on drug release from hydroxypropyl methylcellulose (HPMC, hypromellose) matrix system has been investigated. A model formulation containe