Perforated coated tablets for controlled
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Arne G. Hansson; Angela Giardino; John R. Cardinal; William Curatolo
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Article
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1988
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John Wiley and Sons
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English
β 359 KB
Tablets with a central hole and a water-impermeable coating were prepared. These perforated coated tablets (PCTs) dissolve and release drug through the central hole only. In vitro release of the model drugs sodium benzoate and benzamide from PCTs occurred at a constant rate up to 80% release. The ze