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Drug metabolism in the novikoff hepatoma. Evidence for a mixed function oxidase system and partial purification of cytochrome P-450 reductase

โœ Scribed by Susan E. Saine; Wan-Fen Fang; Henry W. Strobel


Book ID
115734843
Publisher
Elsevier Science
Year
1978
Weight
837 KB
Volume
526
Category
Article
ISSN
0005-2744

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In sensitised guinea-pig lungs alterations in leukotriene (LT) metabolism occurred which resulted in an increase in LTD4 synthesis and a reduction in its catabolism. This may lead to an increase in the concentration of this potent spasmogen in the sensitised lungs. The LTs may cause hyperreactivity