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Drug Metabolism: Hydroxylated Metabolites of Thalidomide: Formation In-vitro and In-vivo in Man

✍ Scribed by TOMMY ERIKSSON; SVEN BJöRKMAN; BODIL ROTH; HENRIK BJöRK; PETER HöGLUND


Book ID
118111163
Publisher
Pharmaceutical Press
Year
1998
Tongue
English
Weight
715 KB
Volume
50
Category
Article
ISSN
2042-7158

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To determine the elimination phenotype of the uricosuric agent benzbromarone 100 mg of the drug was administered as a single oral dose to 11 volunteers on a formula diet; plasma concentration-time profiles of the parent drug and the main metabolites M 1 (l'-hydroxybenzbromarone) and M 2 (6-hydroxy-b