Drug metabolism : current concepts
β Corina Ionescu; Mino R Caira
π Library
π
2005
π Springer
π English
β¦ LIBER β¦
π
Drug Metabolism: Current Concepts
β Scribed by Corina Ionescu, Mino R. Caira (eds.)
- Publisher
- Springer Netherlands
- Year
- 2005
- Tongue
- English
- Leaves
- 431
- Edition
- 1
- Category
- Library
β¬ Acquire This Volume
No coin nor oath required. For personal study only.
β¦ Synopsis
Drug Metabolism: Current Concepts
Corina Ionescu and Mino R Caira
Drug Metabolism: Current Concepts provides a comprehensive understanding of the processes that take place following ingestion of a medicinal agent or xenobiotic, with an emphasis on the crucial role of metabolism (biotransformation). How a sound knowledge of these phenomena is incorporated into the design of effective new drug candidates is also explained. The user-friendly text focuses on concepts rather than extraneous details and is supported by many illustrated examples of biotransformations as well as frequent references to current critical reviews and articles highlighting the nature of research objectives in this vibrant area of medicinal development. The final topic on strategies for drug design relies on the background provided by the rest of the book.
The book includes chapters on
ADME (drug absorption, distribution, metabolism and elimination)
Pathways of biotransformation (Phase I and Phase II metabolic reactions)
Enzymatic systems involved in biotransformation
Induction and inhibition of drug-metabolising enzymes
Factors that influence drug biotransformation
The role of pharmacogenetics
Drug-drug interactions and adverse reactions
Strategies for drug design.
This book is ideally suited as an advanced text for courses in drug metabolism for students of medicine, pharmacy, pharmacology, biochemistry; and for courses in drug design and drug delivery for students of medicinal chemistry. It is also appropriate for professional seminars or courses that relate to the fate of a drug in the body, drug interactions, adverse reactions and drug design.
β¦ Table of Contents
Drug Metabolism in Context....Pages 1-40
Pathways of Biotransformation β Phase I Reactions....Pages 41-128
Pathways of Biotransformation β Phase II Reactions....Pages 129-170
Enzymatic Systems Involved in Drug Biotransformation....Pages 171-208
Induction and Inhibition of Drug-Metabolising Enzymes....Pages 209-242
Factors that Influence Drug Biotransformation....Pages 243-268
Impact of Gene Variability on Drug Metabolism....Pages 269-294
Drug Interactions and Adverse Reactions....Pages 295-368
Strategies for Drug Design....Pages 369-414
β¦ Subjects
Biomedicine general;Pharmacy;Medicinal Chemistry;Pharmacology/Toxicology;Molecular Medicine
π SIMILAR VOLUMES
Drug metabolism: current concepts
β Caira, Mino R.;Ionescu, Corina
π Library
π
2006
π Springer
π English
Provides a comprehensive understanding of the processes that take place following ingestion of a medicinal agent or xenobiotic, with an emphasis on the crucial role of metabolism (biotransformation). This book also explains how a sound knowledge of these phenomena is incorporated into the design of
Current Concepts in Drug Metabolism and
β Gabrielle M. Hawksworth (Eds.)
π Library
π
2012
π Academic Press, Elsevier
Drug Metabolism Concepts
β Donald M. Jerina (Eds.)
π Library
π
1977
π American Chemical Society
π English
<br> Content: Cytochrome P-450 : its role in oxygen activation for drug metabolism / R.W. Estabrook and J. Werringloer --<br/> Synthetic models for the reaction stages of cytochrome P-450 / James P. Collman and Thomas N. Sorrell --<br/> Biochemical studies on drug metabolism : isolation of multiple
Identification and Quantification of Dru
β Shuguang Ma (editor), Swapan Chowdhury (editor)
π Library
π
2020
π Elsevier Science
π English
<p><i>Identification and Quantification of Drugs, Metabolites, Drug Metabolizing Enzymes, and Transporters, Second Edition,</i> is completely updated to provide an overview of the last decadeβs numerous advances in analytical technologies for detection and quantification of drugs, metabolites, and b
Drug Metabolism Handbook: Concepts and A
β Ala F. Nassar
π Library
π
2009
π Wiley
π English
A valuable reference tool for professionals involved in the industry, Drug Metabolism in Pharmaceuticals covers new tools such as LC-MS and LC-MS-NMR along with experimental aspects of drug metabolism. This work fills a gap in the literature by covering the concepts and applications of pharmaceutica