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Drug Metabolism And Disposition At Varying Levels Of Protein And Calories In Human Subjects


Book ID
114909849
Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
164 KB
Volume
43
Category
Article
ISSN
0029-6643

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## Abstract Two methods have been developed for the introduction of deuterium into the doxepin molecule. The key intermediate (6,11‐dihydro‐1,2,3,4‐^2^H~4~‐dibenz[b,e]oxepin‐11‐one, 5) was prepared by condensation of ethyl 2‐bromomethylbenzoate with [^2^H~6~]‐phenol, saponification of the resulting