Drug-induced perturbations in the in vivo distribution of oncological radiotracers—I. 5-fluoro-6-3H-2′-deoxyuridine influenced by nitrobenzylthioinosine 5′-phosphate (NBMPR-P)

Drug-induced perturbations in the in viv

Drug-induced perturbations in the in vivo distribution of oncological radiotracers—II. 5-[125I]iodo-2′-deoxyuridine influenced by nitrobenzylthioinosine-5′-phosphate (NBMPR-P) and acyclothymidine (ACT)

✍ Leonard I. Wiebe; Edward E. Knaus; Wendy P. Gati; Takashi Iwashina; McQueen Lind 📂 Article 📅 1990 🏛 Elsevier Science ⚖ 383 KB

Nitrobenzylthioinosine (NBMPR), a potent inhibitor of facilitated nucleoside transport in vitro and in vivo, and acyclothymidine (ACT), a potent inhibitor of pyrimidine nucleoside phosphorylase in vitro, have been used in an attempt to modulate the biodistribution of 125I-labelled iododeoxyuridine (