Identifying who is at risk of drug-induc
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Shivakumar Chitturi; Geoffrey C. Farrell
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Article
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2011
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John Wiley and Sons
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English
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In the classical form of alpha1-antitrypsin (AT) deficiency, a point mutation in AT alters the folding of a liver-derived secretory glycoprotein and renders it aggregation-prone. In addition to decreased serum concentrations of AT, the disorder is characterized by accumulation of the mutant alpha1-a