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Drug-Induced Liver Injury, Dosage, and Drug Disposition: Is Idiosyncrasy Really Unpredictable?

โœ Scribed by Lewis, James H.


Book ID
122289838
Publisher
Elsevier Science
Year
2014
Tongue
English
Weight
206 KB
Volume
12
Category
Article
ISSN
1542-3565

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In the classical form of alpha1-antitrypsin (AT) deficiency, a point mutation in AT alters the folding of a liver-derived secretory glycoprotein and renders it aggregation-prone. In addition to decreased serum concentrations of AT, the disorder is characterized by accumulation of the mutant alpha1-a