Linear IgA disease (LAD) is characterized by circulating and tissue-bound IgA antibodies against heterogeneous antigens in the cutaneous basement membrane zone. In most cases the cause is unknown, but a minority of cases has been drug induced. We report a 76-year-old man who developed an acute blist
✦ LIBER ✦
Drug-induced linear IgA bullous disease following antibiotics
✍ Scribed by Todd P Wiadrowski; Catherine M Reid
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- English
- Weight
- 98 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0004-8380
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✦ Synopsis
SUMMARY
A 69‐year‐old woman presented with pneumonia and subacute bacterial endocarditis. Nine days after intravenous vancomycin and ciprofloxacin were commenced, the patient developed a bullous mucocutaneous eruption. Clinical presentation and histopathology were consistent with drug‐induced linear IgA bullous disease (LABD). The patient’s lesions resolved with cessation of antibiotics. A review of the features of drug‐induced LABD and the drugs that have been implicated are presented.
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