Preclinical risk assessment of drug-indu
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Adam Hargreaves; Johannes Harleman
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Article
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2011
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John Wiley and Sons
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English
⚖ 319 KB
## ABSTRACT Drug‐induced changes in prolactin signaling may obscure interpretation of preclinical toxicological endpoints. However, with informed consideration, classic hallmarks of hypo‐/hyperprolactinemia can be recognized in short‐ and long‐term rodent bioassays. Findings can be supported and ex